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Most adverse effects have been mild and transient and have rarely required the withdrawal of therapy Cardiovascular bradycardia: congestive heart failure, intensification of AV block: hypotension, paresthesia of hands: thrombocytopenic purpura, arterial insufficiency, usually of the Central Nervous System lightheadedness, mental depression manifested by insomnia, lassitude, weakness, fatigue, reversible mental depression progressing to catatonia, visual disturbances, hallucinations: an acute reversible syndrome characterized by disorientation tor time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and Gastrointestinal nausea, vomiting, epigastric distress, abdominal cramping, diarrhea, constipation, mesenteric arterial thrombosis, ischemic colitis Allergic: pharyngitis and agranulocytosis, erythematous rash, fever combined with aching and sore throat, laryngospasm and respiratory distress.

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